Depression & Your Brain

Mental health is brain health.

Depression doesn’t just affect how we feel, it affects how our brain functions. Left untreated, chronic depression can shrink brain regions involved in memory, focus, and emotion regulation.

But the good news is, depression is treatable. And caring for our mental health is a powerful way to protect our brain, for today and for the long term.

Brain Benefits of Treating Depression

• Improves memory, focus, and executive function

• Reduces inflammation in the brain

• Supports better sleep, which is essential for brain recovery

• Boosts motivation and energy for healthy habits

• Protects brain structure in areas tied to learning and mood

What the Science Says

• Chronic depression is linked to smaller hippocampal volume and faster cognitive decline.

• Treatment, whether therapy, medication, or lifestyle changes, can reverse many of these effects.

• Reducing depressive symptoms is a key strategy in lowering dementia risk.

Want to better understand how depression, anxiety, and mood affect our brains? Visit our Resources & Studies page and select on Depression & Brain Health to explore the research.

Take the Next Step

Curious how your mental well-being may be shaping your brain health?
Healthy Brain Plan helps you reflect on your current habits and guides you toward supportive, evidence-based changes, all at your own pace.