🧠 Low-density lipoprotein cholesterol levels and risk of incident dementia: a distributed network analysis using common data models

Keeping LDL (“bad”) cholesterol low could help protect your brain from dementia.

Published In: Journal of Neurology, Neurosurgery & Psychiatry
Date: June 2025
Authors: Lee, M. et al.
Link to Study: https://doi.org/10.1136/jnnp-2024-334708

Summary
This large study analyzed data from over 100,000 patients and found that people with low levels of LDL cholesterol (below 70 mg/dL) had a significantly reduced risk of developing dementia, including Alzheimer’s disease-related dementia. Statin use also offered additional brain-protective benefits in those with low LDL levels. The findings suggest that maintaining healthy cholesterol through medication or lifestyle may help prevent cognitive decline.

Key Takeaways
✅ LDL cholesterol levels under 70 mg/dL were linked to a 26–28% lower risk of dementia.
✅ Levels under 55 mg/dL still showed an 18% risk reduction.
✅ Statin use further lowered dementia risk by 12–13% among those with low LDL.
✅ Personalized cholesterol management could be a key strategy for brain health.
✅ The study used rigorous data from 11 hospitals, enhancing reliability.

Why It Matters for You
Managing cholesterol isn’t just good for your heart, it may also protect your memory and thinking skills. Talk to your doctor about checking your cholesterol and whether statins or other strategies might be right for you.

Citation
Lee, M., et al. (2025). Low-density lipoprotein cholesterol levels and risk of incident dementia: a distributed network analysis using common data models. Journal of Neurology, Neurosurgery & Psychiatry. https://doi.org/10.1136/jnnp-2024-334708