Being physically active in your 50s, 60s and 70s could significantly lower chances of developing dementia – early adulthood activity may matter less. 🏃♀️
Published In: JAMA Network Open
Date: November 2025
Authors: Marino et al.
Link to Study: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2841638
Summary
This long-term study from the Framingham Heart Study followed over 4,300 adults across three age groups: early adulthood (30s), midlife (50s), and late life (70s).
Researchers found that being MORE ACTIVE IN MIDLIFE and LATE LIFE, but not early adulthood, SIGNIFICANTLY REDUCED THE RISK OF ALZHEIMER’S AND OTHER DEMENTIAS. The most active individuals in midlife and late life had up to 45% LOWER RISK of developing dementia.
Key Takeaways
✅ Physical activity in your 50s and 70s is linked to a 41–45% LOWER RISK OF DEMENTIA.
✅ Early adulthood activity (30s) showed no significant association with dementia risk.
✅ Moderate to heavy activity in midlife provided the most protective effect.
✅ These results support targeted physical activity promotion as a dementia prevention strategy.
Why It Matters for You
If you’re in your 40s, 50s, or beyond, staying physically active, especially at a moderate to vigorous level, may be one of the best ways to lower your dementia risk later in life. It’s never too late to benefit from movement.
Citation
Marino, F.R., Lyu, C., Li, Y., Liu, T., Au, R., & Hwang, P.H. (2025). Physical Activity Over the Adult Life Course and Risk of Dementia in the Framingham Heart Study. JAMA Network Open, 8(11), e2544439. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2841638